Quote of the week is from Adam Mastroianni:
For example, the National Institutes of Health don’t like funding anything risky, so a good way to get money from them is to show them some “promising” and “preliminary” results from a project that, secretly, you’ve already completed. When they give you a grant, you can publish the rest of the results and go “wow look it all turned out so well!” when actually you’ve been using the money to try other stuff, hopefully generating “promising” and “preliminary” results for the next grant application. Which is to say, a big part of our scientific progress depends on defrauding the government.
The article is mostly about Paul Feyerabend, author of Against Method and self-proclaimed scientific anarchist. Recommended.
📺 Only Murders… Season 4: a better-than-average mystery, now with a movie industry twist that makes it even more self-aware. At this pace I fully expect the show itself to become an independent life form and gain consciousness by Season 6.
Today I learned that Max canceled Scavengers Reign, a show that was in fact the best thing to come out on TV last year. A pox on HBO/Max and a pox on anyone in the TV industry who doesn’t care about good TV. May YouTubers dance on your graves.
🍿 Twisters (2024) was utter garbage as a movie, but pure gold as fodder for a Mystery Science Theater-like viewing at home. Fun was had, until I fell asleep during the last third. Please don’t tell me who won.
📺 The Great British Baking Show had more serious and professional bakers this year than the last, but also more panic attacks, insecurity, large swings in quality and overall lack of composure that kind of reminded me of the NBA. Entertaining nevertheless.
Some weekend links, old and new:
Whether it’s on micro.blog, mastodon, bluesky, threads or in your favorite RSS client, thank you for reading!
Yes, yes, reform the NIH. But while we’re in the finger-pointing mode, why not mention the waste in money and time stemming from the way biotech finance works? Beauty contests, herding around fads, billions of dollars wasted on courting KOLs for treatment that will never be approved. It’s all there…
So, here is a last-minute Hail Marry request that I hope someone will respond to. I run an introductory course on clinical trials at UMBC (BTEC668). Today at 6pm EST we have a patient/caregiver panel where I talk to a few people on why they did or didn’t participate in trials. We may have a last-minute cancelation from a panelist, so if a patient or caregiver has 90 minutes to spare this evening it would be much appreciated! Do email or DM if interested.
The same week Alexey Guzey proposed abolishing the NIH, two more essays popped up:
A few things came to mind:
The last NIH proposal I submitted was about ~150 pages which might indeed seem daunting. But only ~12 pages of that was dedicated to science and will be the focus of study section reviewers (and I can also assure you that I wish I had more than 12 pages to work with). The remainder was some combination of budgets, resumes for all of the personnel involved, descriptions of the data and resources, and contractual language between the NIH and my institution. Nearly all of it was handled by experienced grants administrators in my department who can put these documents together in a matter of hours.