A few months ago I noted that the one of the main reasons biotech was not like tech was its almost unlimited freedom do bullshit. Well, people are able to raise money by BS in other areas as well, as this article shows, but an order of magnitude less because most investors are able to do back of the envelope calculations.
A take on Goodhart’s Law as applied to medicine, this time through the lens of instrumentalisation. If any of these articles tickle you and you haven’t yet read Zen and the Art of Motorcyle Maintenance, please do so now. Ted Gioia recently wrote about the book and its legacy. As an occasional note-taker I am in the minority club of Lila fans as well, though both of Pirsig’s books are due for a re-read.
The point is in the subtitle: “how our bias towards recency in scientific discovery hurts our understanding”. It rings true, and even reminded me of the 26 years it took for CRISPR/Cas systems to travel the path from an oddity to a gene editing platform, until I realized that those 26 years were not spent idling as this review in Cell describes in detail. So, the (lack of) developments in theoretical biology would be a much better example.
Ted Williams was, apparently, a base-ball player about whom John Updike had this to say: “For me, Williams is the classic ballplayer of the game on a hot August weekday, before a small crowd, when the only thing at stake is the tissue-thin difference between a thing done well and a thing done ill.” This applies to any profession you can imagine, and indeed things outside of one’s professional life. People who have the inner drive to do things well even in the absence of stakes could unkindly be called “perfectionists”, but let’s remember that they are the ones who keep the wheels of civilization in motion, in opposition to the hordes of blankfaces, lazy asses and morons.
For the past three years I have been telling people that Clara Barton — known to you as the founder of American Red Cross, if you know about her at all — needs more screen time. This is not because she was a precocious introvert who learned to read at three, or because she practiced blood-letting via leaches on her reconvalescing older brother at age eleven, though I can to some extent relate to both. It is purely because, around the corner from our DC condo that bears her name, there is a museum that bears her name: the Clara Barton Missing Soliders Office Museum.
At its doorway is a replica of the Office’s original sign. As of this afternoon I own both a T-shirt and a magnet with this sign, because, well, just look at it.
Replica of the sign, available for purchase at the museum. The original is also in the museum behind a glass case, where even more of yours truly is visible in reflection form. For a clean version of the sign check out the museum website.
Between the years 1865 and 1868, Ms. Barton used all her free time from the job in the US Patent Office as one of the first five female employees — and the first one paid the same as men — to help families of Civil War soliders find the fate of their loved ones, all 70,000+ of them who went missing, all having various degrees of literacy, before the phone, telegraph, or even indoor plumbing. The office was the nervous center of the operation that worked as a message exchange, and Barton was the center of the office which she loved so much, that she had her own bedroom narrowed so that the office could expand.
Clara Barton's bedroom. The wall to the left is the one she moved. It was, luckikly, not load-bearing, unlike another wall she knocked down for the same purpose to the consternation of her landlord who loved what she did so much that he forgave her.
This is the first angle of the story: a procedural show with one main missing solider case per episode, several smaller ones in the background. Some of these could be played for comedic relief: not all soliders wanted to be found and the museum highlighted some interesting corespondence between Barton, a distressed family, and a man who wanted Barton to mind her own business and not have his name plastered all over pubic notice walls.
The second angle is Barton’s main employer, which is the US Patent Office which is just two blocks north and now houses our favorite Smithsonian museum Or rather two museums, the National Portrait Gallery and the Museum of American Art. These are also not strangers to strong independent women. and which, from 1836 until 1877 housed tens of thousands of minitature models, one for each patent filed. Would Barton had known anyone there? Could any of the patent models have helped her crack a case? Is there a Q of the Bartonverse lurking somewhere in those Greek Revival halls? The mind tingles with the possibilities.
The third angle is the setting. This is Washington DC just after the Civil War. The only cobblestoned street is Pennsylvania Avenue, everything else is dirt central onto which throngs of people empty out their chamberpots while pretending to live in a civil society. This is Clara Barton on Christmas Eve — and the eve of her birthday — in 1861, as tens of thousands of Union Army recruits and ancillary war staff are pouring into town:
The quote, as seen in the Museum.
Our big city, grown up so strangely like a gourd all in a night; places which never before dreamed of being honored by an inhabitant save dogs, cats and rats, are converted into “elegantly furnished rooms for rent,” and people actually live in them with all the city airs of people really living in respectable houses, and I suspect many of them do not know that they are positively living in sheds, but we, who have become familiar with every old roof years agone, know perfectly well what shelters them.
An observation as valid today about a $4,000 per month row house in Adams Morgan as it was back then about a $7 per month boarding house room further downtown. I am not a fan of today’s issues creeping into (a)historical shows but this is the real deal: an expanding city with murderous architecture, as seen through the eyes of a whip-smart, energetic, ambitious woman.
Of course real life is so much more interesting than any procedural candyfloss could possibly contain. These were only three years in Barton’s life. Before that she created a public school out of nothing only for it to be taken from her and given to a male prinicpal; became one of the first women employees (but not before being fired from the job and then reinstated by Abraham Lincoln); tended to soliders and coordinated provision of medical supplies to such extent that she was called “the angel of the battle-field”; and seduced a (married) Lt Colonel who continued being so smithened by her that her photo graced the family mantelpiece upon his return. Burnt out after three years spent finding missing soldiers, she went to Europe to recuperate by doctors orders only to end up assisting civilians caught in the Franco-Prussian War and learn enough about the Geneva Convention and the International Committee of the Red Cross to prostelytize for both upon her return to America, picking up different causes well into her 80s. Exhausted just from typing this, I cannot imagine being the person who lived it. And I can’t wait to read about it in detail.
But wait, there is more. The whole Missing Soliders episode of Barton’s life was, well, missing from the records, and how we found out about it deserves a sub-plot of its own. As the Capital One Arena — back then the MCI Center — was being built, various speculators tried to cash in on the potential revitalization of the neighborhood. One of them was the United Stated government, who bought up almost an entire derelict block of warehouses and abandoned storefronts boredered by 6th, 7th, D and E street Northwest in order to flip them to developers. While inspecting one of those properties, a GSA employee called Richard Lyons found a treasure trove of Clara Barton artefacts and realized the building in which they were housed had to be protected.
An interview with Lyons is playing on loop in the Museum.
In the HBO show he should be played by Bryan Canstron.
The problem was, he couldn’t just go to his employer and tell them that he shouldn’t be allowed to continue doing his job. At least he was sufficiently affraid of the federal government, back in 1996, to have to devise a different plan. He wrote a letter to the GDA under a pseudonym — Edward Shaw, the landlord — in which he implored them to look into the matter further. And they did! That and several surrounding buildings were reconstructed and preserved, and the office now houses the museum which is itself in care of the National Museum of Civil War Medicine whose wonderful staff provided most of the above information.
Still, it would be nice to have some other museum — looking at you, National Portrait Gallery — have a Clara Barton shelf. Tesla toiled in semi-obscurity for decades, and look at him now. Here is hoping for a similar Barton revival.
Proactive vs Reactive DDAVP: The Clamp Finally Faces an RCT from Joel Topf is a perfectly good hyponatremia article if you are into that sort of thing, but what got me interested was the preamble:
Note: This was one of my first posts on Roon.com If you are an American physician who likes to chat about medicine, you should sing up.
Roon.com is “a community for physicians to connect, share knowledge, and shape the future of medicine.” A walled garden for physicians? Made and funded mostly by ex-Pinterest people? Sign me up!
Dave Winer asked me a question about APIs. A friend of mine, who is also an oncologist and a big fan of Mad Men, upon seeing the interaction: “This would be like Matt Weiner asking me for advice on a short story I wrote”. Indeed!
Behind a paywall, but well worth subscribing to for the unusual perspective of a West coast American who has spent so much time in the Balkans that her thinking about world affairs is fresh and unique. When bombs fell in Iran and Americans started talking about regime change, all I could remember was the summer of 1999 when Nato bombs extended the Serbian zombie regime’s lifespan by a year. Lynch explains the how and why better than I ever could.
You could also call this dichotomy thick and thin culture, as Chris Arnade did not so long ago. Although religion features only briefly and superficially, is it not mostly about religion?
Summary: “Market crashes aren’t accidents—they’re board-clearing strategies that consolidate power while the rest of us lose everything.” The diagnosis is right though I can’t say that I understood Butler’s solution which was, if my reading was correct, to play dead?
The list of indignities Wigglesworth suffered from various dcotrors was horrifying and I wondered for a moment where in America medicine was still practiced in that way (the VA?). Then I saw that she was Dutch and things made even less sense. Say what you want about the Lovecraftian horror that is the American “health” “care” system — second in Cthulhu-ness only to its system of immigration — but doctors are for the most part the least paternalistic one can find anywhere in the world, and to a fault.
As a heavy em dash user myself, I can only concur.
Healy will soon have a new book out, or rather a revised edition of his book about data visualization. Quarto is the open-source Rube Goldberg machine he used to create it. Particularly salient was the transformation of Quarto’s output into professional print, which unlike the online version required much human judgement and fiddling. Yay for humans, and yay for physical books .
Lohr passess Gemini through the same gauntlet of tests her students went through. The more abstract the task the worse it gets, particularly with regards to critical thinking. Kind of important if we want generative AI to perform peer review! Though again, the state of human peer review is bad enough that I don’t think it would be that much worse.
Or rather, how to keep the independent blog community going. He had me at “Screw Discord”.
The same thoughts have crossed my mind and even though I keep calling it the naturalistic fallacy, Wikipedia says that the correct term is appeal to nature. However you call it: homo sum; humani nihil a me alienum puto, in its widest interpretation.
I want to do more to support blogrolls and recommendations between the apps. Need to explore this more. For the API, there is a very sparse help page here which I’ll be expanding later this week.
That was Manton Reece in response to my question about Inkwell, an RSS feed reader. And with that sparse help page, Gemini sucesfully completed my request to create “Inkling”, an Emacs client for Inkwell which uses Microbe to compose posts with quoted text, as I’m doing now. It can even bookmark posts using micro.blog bookmarking service.

Dave Winer wondered how he would fit Inkwell into his life. Thanks to Manton’s continued use of open APIs — and with much help from Gemini — I don’t have such dilemmas.
Update: inkling.el is now available on Github, on the Microbe project page. Inkling depends on Microbe for the auth token, so anyone brave enough to try may as well get both!
Here is a quick update to my Now page, which for whatever reason I only get to do while traveling. Or maybe not so quick — by the time I completed, our flight (finally) took off.
Coffee is the second item in this blog’s tag line, yet I feel that I haven’t mentioned it much lately. This is mostly because I believe that, after 10 or so years experimenting, we have settled on a decent routine of 80% pour over, 15% home-made espresso drinks, and 5% drinking out when traveling because bringing the coffee-making aparatus with us was not worth the hassle.
These 5% are killing me, because “take-out” cofee in America is too expensive for what you get.
Note the quotes in “take-out”. In most of the world, a coffee shop is a place where you sit down to get a cup. A waiter or waitress comes in to take your order, and then brings it to your table in a proper ceramic vessel which you sip while sitting down at a table chatting to your friends, reading a book, penning the great Spanish/Greek/Serbian novel or what not. Ordering at the counter and having it poured in a plastic-lined paper cup is gross. Sipping a drink through a platic lid while rushing down the street to get to your next meeting is even worse.
But these are factors tied to culture, economy and lifestyle that may not be modifiable. What can be changed is how Americans view the humble capuccino. Anywhere in Europe, a capuccino is a drink made of crappy beans that you adulter with plenty of milk foam and some cocoa dust on top for added aroma and taste. The cost is around 1.5 to 2 euros, or around $2-2.5. In the US I have been served a mediocre latte with a thin layer of foam, beans that were way too good to be in a capuccino with too much milk and a thicker layer of foam, overroasted beans with luke-warm milk and no foam, and even a concoction poured over ice, all under the name of “capuccino”, served in a plastic cup and meant to be drunk through a tiny hole in its plastic lid, all well over $4 and up to $7 for a bucket of that slop called a “venti capuccino” at an airport Starbucks.
I mean, what are we even doing here?
Yes, if you use your single-origin organic beans from Ethiopia it may take $5 per cup to break even. But the point of the mily espresso drinks is to use up the mediocre over-roasted beans you have to make something people can enjoy. Save you expensive light roasts for pourovers and aeropresses.
On the opposite end, Starbucks, your beans are perfect for a capuccino but what this drink also neads is foam. And good foam requires a tiny modicum of attention from the barista who should not be handling five other orders, most of which are for oversweetened beverages which have nothing to do with coffee.
To be clear, the quality of coffee an American can get is over and above anything available to the average European and I would rather be a coffee enthusiast here than anywhere else in the world. OK, maybe Colombia, but that has its own risks. But Americans are yet to experience the affordable capuccino revolution and I hope that it happens in my lifetime.
Unlike most of PKD’s work, this was my first time reading The Three Stigmata of Palmer Eldritch. I wonder what my thoughts would have been a few decades ago had I gotten to it at the same time as the rest of his novels, but now I cannot help but admire what Dick achieved and how prescient he was, yet again.
The first achievement was to do with words what Satoshi Kon did with images in all of his works, Paprika most of all. Perspectives change and timelines shift mid-sentence, delirious hallucinations become matter-of-fact reality, all without losing the reader. This is only ocassionaly done for comedy; more often, the result is horror of the Lovecraftian kind — Eldritch is right there in the title. One can only imagine what Kon would have done with this book, or with Dick’s similarly reality-bending Ubik. I am, of course, not the first person to have made this observation.
The second was to see what the religion of conumerism will bring, decades before it become obvious to everyone else: alienation, blurred reality, despair. Their physical manifestations — (a metal hand, artifical eyes, deformed jaw — are the titular three stigmata. The Man in the High Castle had religious undertones; fitting for a book of its title, The Three Stigmata… brandishes a religious foghorn.
The third, unintentional achievement, was to bring into focus what I find particularly pernicious about LLMs: I get a visceral reaction, revulsion, to its common turns of phrase. Is this not a good thing, you ask? After all, it kept me off Xitter and most of Substack, which are now inundated with computer-generated text. But no, the revulsion is there even in texts written years ago: this has to be AI, I say to myself, only to see that the article was from 2018. Much like Dick’s protagonists who keep questioning their reality and see the Eldritch stigmata in everyone and everyhing, even themselves, long after exposure to the transcendental drug which is the book’s McGuffin, I have overcalibratted my bullshit detector to find fault in the most innocuous turns of phrase.
Worst of all: am I myself now writing things that someone will mistake for AI — instead of human — slop?