Felt a tap on my shoulder while sitting on a Mall bench and it was this fellow (gal?), hustling for nuts. Did not mind getting up close.
🍿 Project Hail Mary (2026) was the perfect family movie that pushed all the right buttons.
Yes, you should go see it, even if you haven’t read the book. And do bring the kids.
Per Tanner Greer, China is all-in on leading the new industrial revolution, which will of course first be a revolution in science and technology. My only insight into the tech part is that Chinese companies now make the most innovative earphones and the most electric cars, and from reading Apple in China I have a vague sense that they were contract manufacturers in those fields first, then perfected the craft and outdid their former employers.
Most relevant to the world is what they But who are “they”? CCP leadership which sets the tone, startups and conglomerates which do the actual legwork, or the provincial bosses who act as intermediaries? I won’t even pretend to know. have done and will do with renewable energy, batteries, quantum computing and the like. The most relevant to me is what they are doing with biomedical research, particularly in cell & gene therapy. And as the field progresses from discovery to manufacturing — both research-grade and commercial — to clinical trials and actual practice so does the extent of their involvement.
On the discovery side, Chinese authors have already overtaken their American counterparts in the number of papers in top scientific journals. A crude metric for sure — and let’s not get into the whole peer review debate — but it is a measure of general lab activity. Determining whether China overtaking the US is a direct or indirect result of American sinophobia or evidence that the sinophobia was justified I will leave as an exercise for the reader.
In manufacturing, China is in the “let us do your work for you” stage. Not a week goes by that I don’t get an email from a China-based CDMO Contract Development and Manufacturing Organization, which just to make things confusing is often shortened even further to Contract Manufacturing Organization, or CMO, which means so many different things within the same field (Chief Medical/Manufacturing/Marketing Officer, anyone?) that it has become ridiculous. and WuXi Biologics — headquarters in Shanghai — is among the top 5 companies of that type in the world. These companies specialize in being taught how to do things and then doing them at scale, picking up a few things about process development and optimization on the way. Why the US would not want CDMOs from China was so obvious that the bill forbidding federally funded entities from contracting with them sped through Congress, though not after being revised to not explicitly mention WuXi by name.
“They” are not taking the same approach with clinical trials: a wise decision on their part, since the only thing they could have possibly learned from American trialists was inefficiency and bloat. No, the big push is for investigator-initiated trials which can speed up approvals — they only require local oversight, not a national FDA-equivalent to give their blessing — and get cell & gene treatments to patients within weeks, provided of course that they are manufactured in China.
An eternity ago I wrote about two different types of trials, ones meant to introduce new treatments and others meant to establish guidelines and prune less effective therapies. I argued that the regulatory burden for the two should be different, since the latter — Set 2 as I called them — are clearly less risky and carry less uncertainty. We have of course already experienced the world of unregulated trials of new therapies, and it was not pretty. With its IIT push, China is speeding them up further. The risks are clear, but who benefits?
Top of mind are the patients who will get effective treatments sooner. The invisible graveyard will shrink! But of course most treatments won’t work and most patients who take part in IITs and their family members will have spent much time, some even money, to get false hope. A much larger proportion of the beneficiaries will be companies that hit a false positive, and in single-center IITs of small sample size there will be many of those. They will of course be willfully ignorant of the fact that their high response rate in a 10-patient single-arm open-label trial was spurious, but will instead get just enough conviction to pass on the asset to the greater fool. And so will the roulette wheel keep spinning, fueled by financialization that somehow ends up being the root cause of most of the world’s current ills.
I fully expect the American biotech establishment to learn the wrong lesson from Chinese IITs and instead of feeling relief that someone else is taking on the foolish risk be pressured into copying them. Here is to the steadfast box-checkers and blank faces whom I trust to put on the brakes.
Felt a tap on my shoulder while sitting on a Mall bench and it was this fellow (gal?), hustling for nuts. Did not mind getting up close.
Just shy of 100 small-format pages, On Skibidi was a pamphlet more than a book, and a worthwhile read for this geriatric millennial who somehow managed to raise a handful of generation alpha children without once resorting to Skibidi Toilet.
Walker built his meme-explainer career on Skibidi so of course he would read all sorts of things into it: any time he mentioned dialectics or some other high-falutin’ sociology term my eyes rolled so far back into my head I would catch a glimpse of my own retinas. But there is an undeniable attraction to the screen-within-a-screen format; I remember being confounded, as a six-year-old, by the movie theater scene from Annie. How on Earth did they film actors watching other actors, and was anybody filming us watching those actors who watch the actors… which I guess was my first introduction to mise en abyme even though I only found out about the term from Walker. Coupled with quick cuts and catchy music, it seemed infinitely more appealing than the umpteenth ASMR unboxing video.
But of course now it is me overexplaining things. As with Joe Rogan, and Taylor Swift, and any other winner in the winner-takes-all extremistan world of content creation and consumption, the most likely reason why Skibidi Toilet became so popular was simply because it was popular. And to learn more about that, Fooled by Randomness would be a better bet than On Skibidi.
A lovely early afternoon tea and French pastries spoiled because of chatter from a nearby table — in Serbian! — about “quantum medicine”. I don’t care if University of Chicago conned someone into funding research on it, the whole field is Scientology-level bullshit.
🍿 The Plastic Detox (2026) was too sensationalist for my liking, but you can’t escape the message: petrochemicals are all around us, and their introduction coincides with the rise of some alarming health statistics. The documentary anchors on fertility; I am more concerned about the rise in some cancers that can’t be explained away by increased screening. Regardless, it is good to know that our Oral-B electric toothbrush can come with a bamboo extension.
A missed parenthesis obliterating all reference-style markdown links in this post along with other people’s attempts, good and bad, finally pushed me to add a proofreading step before hitting C-c C-c in Microbe. In the latest version, a C-c C-p will send the draft post to Gemini 2.5 Flash with this prompt:
The prompt itself was, of course, suggested by Gemini 3.1 Pro, as was all of the actual LISP code to implement proofreading.
You are a strict, technical copy-editor. Your ONLY job is to fix spelling mistakes, typographical errors, and invalid Markdown and Hugo shortcode syntax. You MUST NOT alter the author’s voice, style, phrasing, vocabulary, or structural choices. Output ONLY the corrected text. Do not add conversational filler, introductions, or explanations.
The main reason for the step were annoying shortcode mistakes that would lead to mangled posts, or even more often posts not even making it through Micro.blog’s build leading to minutes (minutes!) spent digging through error logs. But of course there were many, many more spelling mistakes. Last week’s Clara Barton post alone had a whopping 14!
So much red…
Whatever Gemini sends back, Emacs shows in split-screen view with errors in the old text marked in red and the new and improved version marked below in green. For each change, an a accepts and a d declines the suggestion. Easy!
Having said goodbye to Google years ago I can see the irony in picking Gemini to be my go-to LLM and at some point I will switch to an offline model, Doctorow-style. Until then, Gemini is it, thanks to the blandness of Google and its reliability (and it is saying something about the competition when the master of killing services for no good reason is reliable by comparisson).
📺 How to get to Heaven from Belfast happened, I imagine, when the Derry Girls creator Lisa McGee saw the abomination that was Bodkin and asked Netflix to fund a true (Northern) Irish mystery. Here is hoping that the Netflix fairy doesn’t realize how good of a show this is, and approves Season 2.