🍿 The Holdovers (2023) shows that not making ‘em like we used to was a matter of choice not fate. Some people still have it in them to make beautifully shot, perfectly paced, subtly acted movies with a complex message. Here’s hoping it becomes a Christmas classic.

One very good use case for ChatGPT is… actually chatting. Who knew?

I was waiting for someone at a restaurant and had 10 minutes by myself — a rarity these days. Instead of scrolling through one social network timeline or the other, I opened up the ChatGPT iPhone app, and learned that the only Leonardo painting in the Western hemisphere was right at my doorstep. Also learned that there are only 20 paintings by Leonardo and more than 300 by Rembrandt, and a few other tidbits.

Are any of them true? Well, trust but verify as they say, but why should I trust it any less than a random X account? Or worse yet, a non-random threadboy — now there’s a useful word I saw just recently — who posts unsourced graphs and opinions-as-facts.

Now sure, X and other social networks have upsides, like bonding with fellow humans over topics of joint interest. But these are for the most part shallow connections, empty calories for our socialite stomachs. A more stable and sustainable equilibrium for most people, certainly for me, could be real-life interactions for socializing and algorithms for tickling the mind without any pretense that we would be buddies. Social networks try to be both but are not great at either, the same way pickup trucks try to be both a car and a truck but are mostly gas-guzzling parking spot-hogging behemoths, and at the same time the most popular vehicles in the US. So, a perfect analogy.

From this perspective, ChatGPT’s forgetfulness is an excellent feature. It remembering prior conversations would bring it a step closer towards parasocializing, making it even worse than human social networks. I have no doubt that the feature is coming any month now, if it’s not already here. If and when it comes will the the point when X/Threads/Bluesky et al should sound the alarm — or introduce friendly algorithms of their own.

🏀 “The Wizards lost their 13th straight game Thursday night and have the worst record in the NBA, but at least Jordan Poole scored a season-high 34 points against the Lakers.”

No comment, truly.

Three or so years ago I started a blog post draft titled “Twitter as a dark forest”. Unsurprisingly, I never finished it — and now I can delete it knowing that someone has formulated the issue better than I ever could have, and earlier. There is even a book out which, yes, I’ve ordered. (↬Waxy.org)

This morning I learned that one of the many plot lines in the British TV show Bodies has been lifted from real life:

The Tichborne case was a legal cause célèbre that captivated Victorian England in the 1860s and 1870s. It concerned the claims by a man sometimes referred to as Thomas Castro or as Arthur Orton, but usually termed “the Claimant”, to be the missing heir to the Tichborne baronetcy.

It goes without saying that the real-life Claimant was not as successful as the fictional one — this is why Wikipedia makes for better reading than most fiction.

“Maybe that’s why young people make success. They don’t know enough. Because when you know enough it’s obvious that every idea that you have is no good.”

This was Richard Feynman per the James Gleick biography, and he was correct! Biomedicine is now in this position, as I wrote yesterday.

Glenn Fleishman has a new book project on Kickstarter, and it is the easiest backing decision I’ve made in years. I mean, just look at that sample chapter. It’s called How Comics Were Made: a Visual History of Printing Cartoons and here’s hoping it makes it.

The Medical Journal of Record The New York Times. The link is to a gift article. has an excellent story on Kawasaki disease out today which reminded me of Balkan endemic nephropathy, another rare disease with an unusual and infectious disease-like distribution. ⊕ Note that prevalence and distribution are where the similarities end. Kawasaki disease is a vasculitis (inflammation of the blood vessels) that affects children and young adults. Balkan endemic nephropathy caused your kidneys to shrivel up and stop working, and affected the middle-aged and the elderly. It had no known cause back when I was in medical school (which was — gasp — 20 years ago), but it has since been tied to accidental consumption of a certain plant. Well, accidental in the Balkans but intentional in China, where it was used in some traditional medicines and could cause “Chinese herbs nephropathy”, which was like the Balkan version on speed. Note that I am referring to both BEN and CHN in the past tense, but should probably temper my enthusiasm: even though we know what’s causing them and how to prevent them, their prevalence has decreased but is not zero.

The genetic revolution has been great for many aspects of medicine, but it has also made us a bit lazy. The promise of the late 1990s and the early 2000s has been that we would fine the genetic cause of most diseases, and would be only a step away from solving them. While we certainly found many genetic disorders, most of the are in the ultra-rare category and tied to newly-established diseases that were previously only described as syndromes. The “big” diseases — hypertension, type 2 diabetes mellitus, major depression and the like — are as unknown as ever, their cause described as “multifactorial” which is code for “we don’t know”. Stomach ulcers were also thought to be multifactorial until we found out they were mostly caused by a bacterium. A similar thing seem to be happening with multiple sclerosis, which seems to be caused by a virus, one that was mostly thought to be an unavoidable nuisance but is now a vaccine target.

But haven’t we already discovered all the big bad bugs? I sincerely doubt it. We have trouble identifying even larger organisms Also a gift link, this time to The Washington Post. I’m on a roll today. — there could be hundreds of disease-causing creatures and substances that we don’t yet know about because we can’t see them, can’t grow them, and/or don’t know where to look. And we terrifyingly bad at looking for anything but the obvious — there are parts of our own anatomy that we’ve discovered just recently.

So, I know that we will find the cause of Kawasaki disease and can only hope that it will be soon. I also hope that we will find the one main cause of the obesity epidemic. Add in essential hypertension and psychiatric disorders in there. Much money has been spent on discovering the genetic factors of these diseases. Now that we know that genes play but a small part in most of them, maybe it’s time to reallocate the funds.