• V.H. Belvadi: Working with the end in sight. ⊕ ᔥPhil Bowell, who also noted the beautiful site design. Matches my own experience with Zettelkasten/Slip-box systems, in that none of the very productive people in academia I know actually use anything close to them. Belvadi is sticking to markdown files edited in BBEdit; I am partial to DEVONThink and TinderBox although both of them can also punt text files to BBEdit, which is on my list of should-learn apps.
• Andrej Karpathy: Chemical hygiene. This list of sensible advice for managing our own environment appeared in my RSS reader as part of the Bear blog discovery feed, with small-a “andrej” listed as the author. Since I found myself nodding along to most of it The risk of chemical exposure while handling paper receipts is overblown unless you work at a cash register, in which case you really should wear gloves. I clicked through to check out this andrej’s other work and lo, it was Andrej Karpathy. Unsurprisingly, his 2025 LLM Year in Review was also quite good.
• Brooklyn Gibbs: how to use the internet again: a curriculum. ⊕ ᔥThought Shrapnel, with a much better re-title. Online literacy for adults and children alike. Note in particular that there exist things outside the web: see Project Gemini for an example of a cozy part of the Internet that is very much distinct from the World Wide Web.
• Matthew Haughey: Recent camping and travel discoveries. We will have a fourth-grader in the household next year which means a National Parks pass for the whole family, so this may come in useful!

• Elizabeth Stice: You Think This Machine’s Your Friend, But It’s Not. A reason to rewatch You’ve Got Mail (1998), which I remember as being significantly worse than the movie that inspired it, The Shop Around the Corner (1940). (ᔥJohn Brady)
• Janan Ganesh: When business and democracy don’t mix. Ganesh agrees that capitalism and democracy are in fact at odds, as noted in the last paragraph of this blurb on Enshittification.
• Doc Searls: Shitting Us Not. Similar topic to the above, with a delightful new (to me) word: fecosystem.
• Bryan Vartabedian: Medicine as the last uncompressed profession. On the unmeasurables of medical practice. Of course, medicine is not the last such profession as any live performer can tell you, it is just one of the last ones that is still in demand and for a list of the others still standing I recommend the wikipedia page on Baumol’s cost disease.

• Jacob Savage: The Lost Generation

A story of white male millennials being blocked from career advancement because of DEI. The fields he highlights are scripted television shows, news magazines and academia which aren’t exactly thriving now but per Savage did back when these policies were being implemented (early to mid-2010s). The rise of the “manosphere” and crypto brotherhood was therefore revenge of the jilted, which sounds plausible. One does not become an NFT peddler because they want to but because they couldn’t fulfill their life-long dream of being a tenured Women’s Studies professor.

Note that only early-career positions seem to have been affected, where people with no skill and/or time to choose among many qualified candidates decided to simultaneously switch from one discriminatory heuristic to another. So maybe not everyone should have done it at the same time (a good policy to follow for any change)? Would a method for unbiased selection of early job candidates have to involve an AI? And what are the demographic of OpenAI and Meta’s leadership again?

• Derek Lowe: Where Are They Now: Verge Genomics

A Y Combinator company tries to use machine learning to discover new drugs. No, they didn’t figure it out and are now pivoting to selling pickaxes instead of digging for gold themselves. Godspeed.

• Hiya Jain: A Case Study In Scientific Coordination

Retelling of the story of penicillin’s discovery and mass manufacturing, which is much more complex than the typical serendipity-is-important (or, sometimes, luck-favors-the-prepared-mind) tale that begins and ends with Alexander Fleming’s accidentally contaminating a bacterial culture with mold. This is not to disparage the more popular variant: a big part of my childhood was soaking up wild tales of invention via Discoveries Unlimited which originally came out in the year of my birth but was dubbed to Serbian and played on repeat on state TV in the early 1990s. Of course, my own children now have something infinitely more majestic than the “Video Encyclopedia” from that show… and use it to play Roblox.

• Azhdarchid: Thematic expression in game design, or: Why Dune (1992) rules

This also took me back! And not only because of Dune, which I played several times through the end and liked much more than the sequel, one of the first real-time strategy games. No, this article is also about It came from the desert and Sid Meier’s Pirates! and many other games that used short-but-sweet bursts of different mechanics to tell a coherent story, which is qualitatively different from a collection of mini-games sold to highlight the multi-functionality of Nintendo’s new controller. I hope an indie game studio somewhere is working on bringing them back.

📸 Day 2 of micro.blog’s Winter Wonder Photo Challenge and the word of the day is cozy.

So, here are some cozy web stickers that will make any office cubicle (or — shudders — an open office) hospitable.

• Merriam-Webster: Merriam-Webster’s human editors have chosen ‘slop’ as the 2025 Word of the Year.. A year behind the times, no? Although, same could be said about Oxford’s.
• eryney marrogi: This paper is being interpreted as something it isnt.. The paper in question being about AI-designed super-proteins, with claims of the proteins' supremacy being somewhat overstated, particularly by the perennial AI alarmist whom Marrogi quote-tweets. Although the thought of humans creating new super-stable proteins by any means, LLM or no LLM, does give me heartburn. Haven’t these people heard of prions?
• Chris Arnade: I just always assumed Oliver Sacks was bullshitting. Hey, I did too, so a profile in The New Yorker to which Arnade refers was no surprise. Caveat lector, always and forever.
• Anil Dash: Cory take decades of fluency in how these systems are broken and serve it up for a mainstream audiences. That’s about Cory Doctorow’s interview for The Daily Show, and I guess I missed the news on Jon Stewart being re-replaced. For a longer pontification from Doctorow, see his conversation with Aaron Bastani.

• Scott Sumner: The Great Depression: Elevator pitch. Wherein Sumner outlines his book on the Great Depression, The Midas Paradox, which I haven’t read but is now on the pile. Even just the outline has brought my level of understanding from zero to a vague sense of what went wrong.
• Ernie Smith: Compartmentalizing. I knew about the shipping container revolution before reading this brief history on Tedium, but I forgot just how much ships themselves transformed to accommodate the new invention to the point of being overoptimized.
• Sasha Gusev: Embryo selection company Herasight goes all in on eugenics. What it says on the tin, and these people are brain-dead morons who want to use polygenic risk scores for the betterment of society. The company’s white paper lists Benefits to future people as the very first item under the section “Moral reasons for embryo screening”. Gusev, a geneticist, has written an excellent overview of why polygenic risk scores are not that straightforward to use for even individual embryo selection and personally I think it is a terrible idea, but to each their own for individual decisions. The betterment of society ploy, however, is playing with fire that already burned through Europe not 100 years ago.
• Jay Caspian Kang for The New Yorker: If You Quit Social Media, Will You Read More Books?. Subtitle: “Books are inefficient, and the internet is training us to expect optimized experiences.” My answer is that it depends, although the author would very much like for us to apply Betteridge’s law in our heads. (ᔥTyler Cowen)
• Kyla Scanlon: Everyone is Gambling and No One is Happy. At this point Scanlon’s essays are starting to blend in with one another, but I would like to highlight this one for pointing out a smart thing Paul Krugman wrote, The link is to his Substack newsletter, not the actual post, because that is for some reason the link Scanlon included in her own essay. Not being a Krugman reader myself I can’t tell if this is what he actually wrote or if it is Scanlon’s clever interpretation. Frustrating. which I understand to be a rare occurrence. Here are three concepts not captured by standard economics analysis that are contributing to the financial malaise:

1. Economic inclusion: Can you afford to participate in society?
2. Security: Are you one broken tooth away from bankruptcy?
3. Fairness: Are you being scammed?

Sounds right.

• Joe Wilkins: McDonald’s Pulls Down AI-Generated Holiday Ad After Deluge of Mockery. The offensive ad is still available for viewing, and I am horrified to report that it is in fact on par with non-AI holiday marketing shlock. Every profession that feels collectively threatened by LLMs has spent decades undermining itself and is now reaping what it sowed, and yes I include many medical specialties here.
• Sam Kriss for the NYT: Why Does A.I. Write Like … That? A brilliant essay with illustrations that would make me blow a fuse if I were to see them out in the wild. Kriss has a blog to which I am now subscribed and also seems to post on this new social network for writers called… Substack? And Curtis Yarvin plus the rationalist buffoons hate him? Worth following!
• Christopher Butler: The Last Invention. “The real threat of AI as ‘the last invention’ isn’t that it will actually end human innovation and put us all out to pasture in a withering culture of leisure, but that we’ll believe it will. That we’ll internalize the narrative of our own obsolescence and stop trying. That we’ll mistake the tool for the maker and forget that the heart that yearns past the boundary is what drives everything forward.”
• Andrew Sharp: Netflix and the Flattening of Everything. I am not a fan of Netflix. In fact, I dread the moment when they gobble up the last thing, idea or person standing on their path to entertainment singularity. And yet I stay subscribed.
• Taylor Jessen on Mastodon: Candidate for Post of the Year. The post in question is a screenshot from Bluesky which perfectly demonstrates end-stage enshittifaction of what used to be the capital-I Internet, but that is beside the point which is in fact funny and true.

• Ruxandra Teslo and Jack Scannell: To Get More Effective Drugs, We Need More Human Trials. I maintain that this will be nigh-impossible to do in the US until we break the healthcare ouroboros. AI as used now, to increase the number of drug candidates without making a dent in the speed of actually testing them, will only make things worse.
• Benjamin Mazer for The Atlantic: Yes, Some Children May Have Died From COVID Shots. Indeed, and the attempts to say otherwise can only Streisand the issue that should have been just a footnote to the long list of historical vaccine concerns.
• Simon DeDeo: Advice for Early-Career Academics, Part I: Mentorship. No-nonsense advice I wish I had 20-some years ago. I particularly like the distinction between mentors, supporters, fans, friendly elephants and noble adversaries. Left unmentioned are the many people who don’t have your best interest at heart.
• Michael Levy on YouTube: “Hurrian Hymn no. 6” (c.1400BCE) - Ancient Mesopotamian Musical Fragment. The Hurrian songs come not from Mesopotamia but from Ugarit, a city in what is now northern Syria which was one of many victims of the Late Bronze Age collapse. One would hope this would put to rest any questions on whether the humans of that age were like us, but then there are people alive now who don’t think their contemporaries are anything like them.

• Gina Kolata for the NYT: Why Some Doctors Say There Are Cancers That Shouldn’t Be Treated. Is the rise in cancer rates due to overdiagnosing tumors that would have been harmless or a true “epidemic” of deadly malignancies? The answer is “Yes”.
• Alex Telford: Going direct: notes on Eli Lilly at a trillion. Why has the valuation (if not true value) of Eli Lilly skyrocketed while the other big GLP-1 company, Novo Nordisk, is in turmoil? The answer is “tech company mimesis”. Girardian.
• Caasey Handmer: Energy Predictions 2025. What is the future of world energy production? The answer is — and this should not be a surprise — “soral”, but good luck to cloudy countries with a NIMBY attitude towards wind power.
• Ben Werdmuller: Why RSS matters? Because you would not be able to read this without it!

• Vincent Rajkumar on X: I’ve been on this platform for 16 years. Here are some tips on how to be productive, and gain influence and credibility on X. Great advice for those attending the 2015 ASH Annual Meeting, but I am not so sure about their utility a decade later. Where is the hematology dark forest?
• Edward Zitron: The Era Of The Business Idiot. The more sociopathic of Taleb’s IYIs become executives; hilarity ensues.
• Cory Doctorow: The Reverse Centaur’s Guide to Criticizing AI. An introduction to Doctorow’s new book, “The Reverse Centaur’s Guide to Life After AI. Astute as ever.
• Chris Arnade: [Why are Americans Unhappy]. Arnade dismantles the $140,000 poverty line idiocy with a side jab at the abundance movement by repeating the insight he has each time he visits a seemingly poorer but more communal part of Europe:

So yes, Americans are materially wealthy and unfulfilled, and the primary problem is cultural—we’ve sacrificed community and meaning to emphasize an archetype built on acquiring as much stuff as possible, but then we have made that unnecessarily hard to do. When you give your citizens a cultural script, built on the material, that promises hard work will lead to success, and then your policy design ensures it doesn’t, people will end up both economically frustrated, as well as spiritually empty, sitting in their living room streaming the latest movie wondering what exactly is the point of life. Or, they will feel they have failed at the material, while also having little else to give them meaning.