“The Reproducibility Project: Cancer Biology was an 8-year effort to replicate experiments from high-impact cancer biology papers published between 2010 and 2012.”
Out of 193 experiments from 53 papers, only 50 (26%) were successfully reproduced, and in those the effect sizes were 85% smaller on average. Scientists at Bayer did the same thing 10 years ago, with identical results: only 20-25% of experiments reproduced.
With foundations like this, it is amazing that there has been any progress in the clinic.