Do you know about a horse named Jim? The one whose tetanus-contaminated serum was used to make diphtheria antitoxin that killed kids:

These failures in oversight led to the distribution of antitoxin that caused the death of 12 more children, which were highly publicized by newspaper magnate Joseph Pulitzer as part of his general opposition to the practice of vaccination.

There is a straight line from Jim to the creation of US FDA, in case you want to remove that particular Chesterton’s fence.