Today’s Washington Post has a good write-up on how genetic engineering of the near-extinct American chestnut tree to make it more resistant to infection went wrong:

After he enlisted the help of Ek Han Tan, a geneticist at the University of Maine, to analyze the chestnut’s genome, they made their discovery this fall: The plants they were working on were, in fact, not Darling 58 trees.

Instead, they found they were working with a different chestnut line — called the Darling 54 — where the gene was inserted in another chromosome entirely, potentially corrupting one of the tree’s existing genes.

…

In a phone interview, Newhouse, the SUNY ESF director, acknowledged the mix-up but said he wasn’t sure what transpired.

“As far as exactly how it happened, we don’t know,” he said. “It must have been a label swap between these two trees that we were working with at the same time” in or around 2016.

The brilliant minds who think engineering mosquitos is a good idea can’t foresee that even a seemingly innocuous clerical error can lead to disaster, never mind the second-order effects to nature if your project succeeds. Whoever’s read Taleb’s Incerto (or some of his tweets) knows better.