Is lithium deficiency an important factor in developing Alzheimer’s disease? A recent paper in Nature provides some convincing evidence, mostly from mice. For example:

Replacement therapy with lithium orotate, which is a Li salt with reduced amyloid binding, prevents pathological changes and memory loss in AD mouse models and ageing wild-type mice.

I know quite a few doctors who would say lithium (carbonate) deficiency is responsible for many behavioral issues in adults, but this is not what they had in mind! (↬Derek Lowe)