🧪 For the five people out there who are interested in T-cell malignancies, one of the last papers we wrote with Dr. Waldmann is now out as early access at Blood Advances. It is a modest phase 1 trial of IL-15 and Campath with interesting results.

“Science gets entangled with politics; it always has and it always will. And every time it happens the reputation of science get damaged. I am of course not a scientist and cannot speak authoritatively to these matters; but I can at least point to some intellectual problems that need to be addressed.”

Full post here. As a scientist of sorts, I can only nod my head in agreement.

The Good Science Project is underselling how good it is. More like this, please. (signatures below the manifesto are a good — heh — example of quality over quantity)

🧪 Good morning to everyone except to whomever is in charge of the eRA Commons service desk. You’d think that a multi-billion dollar operation like NIH would have a decent answering service, with a call-back option, number in line, etc. ★☆☆☆☆, won’t use again (if only)

A marvelous xkcd from a few days ago. This one strip explains the trouble with odds ratios better than hours of premed/med stats 🧪

A big reason Don’t Look Up didn’t sit right with me was its simplistic view of the scientific consensus. “Listen to the goddamn qualified scientists…” bellows Ariana Grande paternalistically.

Meanwhile, qualified scientists from reputable institutions of higher education act as petty and vindictive prima donnas. The linked article is one scientist’s story of having to suffer through years of academic harassment for publishing a paper that rubbed some of her fellow researchers the wrong way. From the abstract:

A naïve researcher published a scientific article in a respectable journal. She thought her article was straightforward and defensible. It used only publicly available data, and her findings were consistent with much of the literature on the topic. Her coauthors included two distinguished statisticians. To her surprise her publication was met with unusual attacks from some unexpected sources within the research community. These attacks were by and large not pursued through normal channels of scientific discussion. Her research became the target of an aggressive campaign that included insults, errors, misinformation, social media posts, behind-the-scenes gossip and maneuvers, and complaints to her employer. The goal appeared to be to undermine and discredit her work.

Goddamn scientists indeed.

Saurabh Jha:

“Today’s Galileos fight over one or two vaccine doses in teenagers, whether the risk of vaccine-induced myocarditis is 1/1000 or 1/10, 000. Nothing encapsulates our pettiness more completely than our probability wars.”

Echoes of Chris Hitchens here.

• 1994: Fifth grade; I am charged with editing the school newspaper. There is an Intel 386 PC at home that is about to be upgraded to a 486 and do something more than run Lands of Lore.
• 1996: Seventh grade; I typeset a book of poems¹. The school newspaper becomes the school magazine — in layout only; the publishing schedule remains haphazard — as I upgrade from Word 6.0 to QuarkXPress
• 2000: High school starts again after a freshman year interrupted by NATO bombing. I make the town library’s official website. It is a php hack job laid out in tables instead of the newfangled and to me unknown CSS; it still wins an award.
• 2002-2008: Med school; I typeset a book here and there and occasionally help out with the library website.
• 2009: Teaching assistant, Institute for histology and embryology, Belgrade School of Medicine.
• 2010: Resident, Internal medicine, JHU/Sinai, Baltimore MD.
• 2013: Chief resident, Internal medicine, as above; I understand the benefits of not being invited to a meeting.
• 2014: Clinical fellow, hematology/oncology, National Cancer Institute, Bethesda MD.
• 2016: As above, but also Chief fellow ex tempore for the joint NCI/NHLBI fellowship; my hatred of poorly-run meetings intensifies.
• 2017: Staff clinician, later to be renamed Assistant research physician, Clinical Trials Team, Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda MD; the 1994 me marvels at the word salad trailing the title.
• 2021: Chief Medical Officer, Cartesian Therapeutics.

I, for one, am glad that blogs are making a comeback. Here are a few I’ve been reading for at least a few months, many of them for years, some for decades.

Applied philosophers

The only true philosophers of our time.

• Mathflaneur (by Nassim Taleb)
• Ribbonfarm (by Venkatesh Rao, who also has a newsletter of half-baked ideas he calls Ribbonfarm Studio)

The new scientists

People without major academic credentials who have interesting ideas about science.

• Alexey Guzey (also see Guzey’s Best of Twitter, and also see New Science)
• Applied Divinity Studies
• Astral Codex Ten (former Slate Star Codex)
• Fantastic Anachronism
• Gwern
• Nintil

The old scientists

People with major academic credentials and interesting ideas, something to teach, or both.

• I am Intramural (from the NIH Intramural Research Program)
• Statistical Modeling, Causal Inference, and Social Science by Andew Gelman
• Statistical Thinking by Frank Harrell
• Stephen Wolfram Writings
• The Mathematical Oncology Blog (see also This week in Mathematical Oncology)

The ludites

People against modernity of one sort or another.

• Axiom of Chance (Simon DeDeo, who does not seem to have a Twitter account)
• Patrick Rhone (who does have a Twitter account)
• Study Hacks (by Cal Newport, whose Twitter account, if real, has been abandoned years ago)
• Wrath of Gnon (who is in fact — and sadly — all Twitter)

People doing their own thing

Unclassifiable but exhilarating.

• Craig Mod (and on Twitter) who walks, makes books, and takes photos.
• Garden of Forking Paths (by Abe Callard, who watches movies)
• Rands in Repose (by Michael Lopp, who manages people)
• The Sephist (by Linus, who makes his own software tools)
• Thought Asylum (by Stephen Millard, who makes other people’s software tools more usable)

Apple enthusiasts

Some tips, a few tricks, many opinions.

• And now it’s all this
• Brett Terpstra (if you have a Mac and use it for more than just browsing the internet and answering email — not that there is anything wrong with that — Terpstra’s tools will save you days of work; he could easily have been slotted in the category above, but the Apple tag predates all and he is an Apple lifer)
• Daring Fireball (by John Gruber)
• Hypercritical (a sadly neglected blog by John Siracusa although what you should really check out is the podcast of the same name which has been out of production for years but still fun and relevant)
• Macdrifter
• Marco.org (by Marco Arment)

Finance-adjacent

Economists and investors, for the most part.

• Global Inequality (by Branko Milanović)
• Marginal Revolution (by Tyler Cowen and Alex Tabarrok who also wrote an excellent textbook in economics which I plan on reading some day, likely in retirement)
• Pseudoerasmus (the last post was in 2017 so I’m not holding out any hope, though he is on Twitter)
• The Rational Walk (see also Rational Reflections and the Twitter account)
• 10-K diver (as close to a blog that a Twitter account can get)

Journalist-cum-substackers

Former or current journalists who now earn some or all of their living by writing newsletters via Substack, which is slowly reinventing blogs (in the sense of reinventing the wheel, not actually making them better and in fact in many was making them much worse).

• Everything Studies (by John Nerst)
• Galaxy Brain (by Charlie Warzel)
• Insight (by Zeynep Tufekci, who is hands down the best journalist currently writing)
• Slow Boring (by Matthew Yglesias)

Company blogs

For when I really want to know when the next update is coming.

• Devonian Times, from the makers of my note-collecting tool of choice, DEVONthink
• The Omni Group, makers of OmniFocus (and OmniGraffle, which I don’t use often enough for it to be essential but which is fairly
• Wolfram Blog, from the makers of Mathematica

There is a crisis in medicine, but not the one you think: ⊕ And not only in medicine, of course.

I have a folder called Articles for them on my desktop. Which never gets opened. It is a like a black hole.

— Venkatraman Radhakrishnan (Venky) (@venkymd) November 15, 2020

90% of what I do on Twitter is email myself interesting articles I see Tweeted only to never be read.

— Aaron Goodman - “Papa Heme” (@AaronGoodman33) February 25, 2021

Reading primary literature is superior to press releases and tweets — it sounds so obvious, but not many physicians act on it. There no prizes to be won for not just following the KOLs[^kol], ⊕ Key Opinion Leaders, the influencers of medicine before influencer became a real noun. Note that unlike the influencers of social media KOLs don’t use the #sponsored hashtag, though there is a hashtag equivalent. nor do you save any time. Quite the opposite: instead of a promoted tweet about the me-too drug de jour falling into your lap, you need to find a way to identify what’s worth your time reading, and also find time to actually read it — not a small achievement, as highlighted by the above tweets.

But then what? Sure, there is profit at the end of the rainbow in the form of useful knowledge, but merely reading a PDF may not result in any knowledge at all, let alone knowledge you can use. Or, as the [underpants gnomes][gnomes] would put it:

I too had a backlog of unread PDFs once, spent so much time organizing files and folders, using this and that program to store the metadata, ⊕ NB: if you write any sort of scholarly texts you will still need a reference manager, no matter what system of organizing PDFs themselves you choose. I recommend Zotero, lest your institution has a requirement for Endnote (which must have quite a salesforce, to so thoroughly insert their buggy, laggy, slob of a program into every academic crevice). trying out plain paper, a Kindle, an iPad or two, thinking it is how I was reading them that mattered and oh if only I could find the perfect setting, under the shade of an old oak tree perhaps, with some peace and quiet, a pen in one hand and a cup of coffe in the other, well, then the unread pile would melt away and all would be good in the world.

But reading is easy, if what you read is useful, entertaining, or both. For most people without visual impairments or dyslexia, the log jam is at Step 2. We don’t want to read our pile of PDFs because, in most post-GME circumstances, there isn’t a clear goal to reading them (lest you have superhuman memory). The clear exception here being board exam and MOC prep, where the goal is obvious and the sources of information are all spelled out. This is particularly true early on in your carreer, when you have nothing to hang your hat on mentally, and few connections to make between what you are reading and what you already know. Sure, you don’t need to keep track of the articles you’ve read if the only reason for reading is to pan them on Twitter. You do, however, want to summarize what you’ve read and save it for future use, be it in a lecture, article, grant proposal or a blog post. So if and when you find a fairly obscure but potentially important fact about this or that cellular pathway in a supplemental figure from a CNS-adjacent journal, and you memorize the fact for later use, and then a year or so later you do use it to make a figure for the background section of a clinical trial protocol, well, what you do not want happening in that case is to spend hours of your life trying to retrace your steps and figure out the original source when a fellow ⊕ Yes, this has happened to me. We do have good fellows. asks where you got the data.

I wouldn’t be admitting to all that if I didn’t think I’ve found a solution. A few years ago, I replaced the unsustainable routine of just-in-time literature reviews for whatever I needed done with a robust knowledge management system — a GTD® © David Allen Co. 2001. It is a good system though. for ideas, if you will. It got to a point where I can read at least one article every day and skim a few more, get the useful information out and into my app of choice ⊕ The app of choice before DEVONthink was Roam, which is a web service and a marvelous one at that, but unfortunately not much into encryption, privacy, and other things people dealing with confidential information like to have in the tools they use., and have all the information I need to write an editorial like this in a morning or two.

As with most of the things I do it is too personal and Rube Goldberg-y to be of use to anyone else, but it started with a forum post and a book, and if you’d like to turn your plate full of PDFs into something more usable may I recommend that you start with one or both of those and see how it goes. Could it be any worse than what you’re doing now?