• Jacob Savage: The Lost Generation

A story of white male millennials being blocked from career advancement because of DEI. The fields he highlights are scripted television shows, news magazines and academia which aren’t exactly thriving now but per Savage did back when these policies were being implemented (early to mid-2010s). The rise of the “manosphere” and crypto brotherhood was therefore revenge of the jilted, which sounds plausible. One does not become an NFT peddler because they want to but because they couldn’t fulfill their life-long dream of being a tenured Women’s Studies professor.

Note that only early-career positions seem to have been affected, where people with no skill and/or time to choose among many qualified candidates decided to simultaneously switch from one discriminatory heuristic to another. So maybe not everyone should have done it at the same time (a good policy to follow for any change)? Would a method for unbiased selection of early job candidates have to involve an AI? And what are the demographic of OpenAI and Meta’s leadership again?

• Derek Lowe: Where Are They Now: Verge Genomics

A Y Combinator company tries to use machine learning to discover new drugs. No, they didn’t figure it out and are now pivoting to selling pickaxes instead of digging for gold themselves. Godspeed.

• Hiya Jain: A Case Study In Scientific Coordination

Retelling of the story of penicillin’s discovery and mass manufacturing, which is much more complex than the typical serendipity-is-important (or, sometimes, luck-favors-the-prepared-mind) tale that begins and ends with Alexander Fleming’s accidentally contaminating a bacterial culture with mold. This is not to disparage the more popular variant: a big part of my childhood was soaking up wild tales of invention via Discoveries Unlimited which originally came out in the year of my birth but was dubbed to Serbian and played on repeat on state TV in the early 1990s. Of course, my own children now have something infinitely more majestic than the “Video Encyclopedia” from that show… and use it to play Roblox.

• Azhdarchid: Thematic expression in game design, or: Why Dune (1992) rules

This also took me back! And not only because of Dune, which I played several times through the end and liked much more than the sequel, one of the first real-time strategy games. No, this article is also about It came from the desert and Sid Meier’s Pirates! and many other games that used short-but-sweet bursts of different mechanics to tell a coherent story, which is qualitatively different from a collection of mini-games sold to highlight the multi-functionality of Nintendo’s new controller. I hope an indie game studio somewhere is working on bringing them back.

📸 Day 2 of micro.blog’s Winter Wonder Photo Challenge and the word of the day is cozy.

So, here are some cozy web stickers that will make any office cubicle (or — shudders — an open office) hospitable.

My font fiddling continues. Google fonts as recommended by ChatGPT are out, Charter, Cooper Hewitt and Source Code Pro as recommended by Matthew Butterick in his delightful Practical Typography are in. Next up, the color scheme.

📚 Finished reading: Enshittification by Cory Doctorow, which is a continuation of his blog posts and essays on the word he coined. I was worried that this would be a pointless pad-job, like what David Graber did for his similarly scatological Bullshit Jobs. But no, the topic is deep and Doctorow’s book explores those depths with competency and good humor.

What I most appreciate is that the solutions aren’t of the end-user “use paper straws” type. The point is not to boycott Amazon, leave all social media, move to a Kaczynski-style cottage; rather it is to put pressure on local, state and federal lawmakers to do their jobs and prevent the country’s slide to full-on technofeudalism. This is another delightful term, popularized by Yanis Varoufakis who himself has direct experience working for a feudal lord, Valve. Yes, there is a book and yes, I it is now on the ever-growing pile. Although, I still plan on canceling our household’s Prime subscription and redirecting the money to EFF.

Note that Doctorow describes himself as leftist and calls people “comrade”, a term at which I tend to recoil. He also sings praises to the EU legislature, of which I am profoundly sceptical. Still. We can agree that Big Tech is too big and that their bosses are too cozy with the government, and that between European Union’s incompetence and the American increasingly corporatized state only one has a straight path to totalitarianism, the final destination of end-stage enshittification.

• Joe Wilkins: McDonald’s Pulls Down AI-Generated Holiday Ad After Deluge of Mockery. The offensive ad is still available for viewing, and I am horrified to report that it is in fact on par with non-AI holiday marketing shlock. Every profession that feels collectively threatened by LLMs has spent decades undermining itself and is now reaping what it sowed, and yes I include many medical specialties here.
• Sam Kriss for the NYT: Why Does A.I. Write Like … That? A brilliant essay with illustrations that would make me blow a fuse if I were to see them out in the wild. Kriss has a blog to which I am now subscribed and also seems to post on this new social network for writers called… Substack? And Curtis Yarvin plus the rationalist buffoons hate him? Worth following!
• Christopher Butler: The Last Invention. “The real threat of AI as ‘the last invention’ isn’t that it will actually end human innovation and put us all out to pasture in a withering culture of leisure, but that we’ll believe it will. That we’ll internalize the narrative of our own obsolescence and stop trying. That we’ll mistake the tool for the maker and forget that the heart that yearns past the boundary is what drives everything forward.”
• Andrew Sharp: Netflix and the Flattening of Everything. I am not a fan of Netflix. In fact, I dread the moment when they gobble up the last thing, idea or person standing on their path to entertainment singularity. And yet I stay subscribed.
• Taylor Jessen on Mastodon: Candidate for Post of the Year. The post in question is a screenshot from Bluesky which perfectly demonstrates end-stage enshittifaction of what used to be the capital-I Internet, but that is beside the point which is in fact funny and true.

• Vincent Rajkumar on X: I’ve been on this platform for 16 years. Here are some tips on how to be productive, and gain influence and credibility on X. Great advice for those attending the 2015 ASH Annual Meeting, but I am not so sure about their utility a decade later. Where is the hematology dark forest?
• Edward Zitron: The Era Of The Business Idiot. The more sociopathic of Taleb’s IYIs become executives; hilarity ensues.
• Cory Doctorow: The Reverse Centaur’s Guide to Criticizing AI. An introduction to Doctorow’s new book, “The Reverse Centaur’s Guide to Life After AI. Astute as ever.
• Chris Arnade: [Why are Americans Unhappy]. Arnade dismantles the $140,000 poverty line idiocy with a side jab at the abundance movement by repeating the insight he has each time he visits a seemingly poorer but more communal part of Europe:

So yes, Americans are materially wealthy and unfulfilled, and the primary problem is cultural—we’ve sacrificed community and meaning to emphasize an archetype built on acquiring as much stuff as possible, but then we have made that unnecessarily hard to do. When you give your citizens a cultural script, built on the material, that promises hard work will lead to success, and then your policy design ensures it doesn’t, people will end up both economically frustrated, as well as spiritually empty, sitting in their living room streaming the latest movie wondering what exactly is the point of life. Or, they will feel they have failed at the material, while also having little else to give them meaning.

• Lily Lynch: How the US Stunted Europe. Short and to the point, no notes. Sufficient to make me re-subscribe to Lynch’s newsletter. She links to her review of Sanna Marin’s biography, which is also no-notes wonderful.
• Chris Person for Aftermath: Horses is Tame. I have never heard of the game Horses before or the controversy surrounding it, so I must assume that Valve, Epic and others who banned it for not sure what exactly have never heard of the Streisand effect. Well done, folks.
• Jim Olds: How Will You Know You’ve Succeeded?. I have panned this career research administrator’s first blog post, but this one was in fact enlightening. You have to keep the funders happy, even if they are an amorphous blob called “the American taxpayer”.
• Dr. Christine Corbett Moran: Scaling Career and Family: Systems Thinking, Public School, Home Enrichment. Advice on raising kids from a couple of scientists/engineers turned entrepreneurs. Useful, if a bit on the spectrum, and I even more thankful we had extensive family support when raising our kids, particularly early on.
• Nick Maggiulli: There is No Substitute for Thinking. What are students who use ChatGPT thinking, if they are thinking at all? Will they be writing texts like the ones above or post AI slop in their middle age? Time will tell.

“The internet is dying on the outside but growing on the inside”, wrote Yancey Strickler last month in a follow-up to his 2019 essay The Dark Forest Theory of the Internet. To avoid misunderstanding, malicious interpretation, competitive intelligence gathering and cancelation, conversations have been moving from the public-facing “social” “media” to gated, invitation-only services (e.g., your favorite Substack author’s members-only discussion forum) and private group chats (e.g., the Let’s Bomb Yemen Signal texts).

But some parts of this Cozy Web are growing faster than others, and as if often the case doctors and scientists are ruled by inertia. Both groups have the perfect setup, in the form of professional societies, to carve off some gated space in which to have potentially controversial discussions without providing fodder to “the enemy”. ⊕ In these kinds of metaphors I always reach out to Venkatesh Rao’s The Internet of Beefs, which explains quite well why the public Internet has turned into a dark forest in the first place. And yet even the most developed online community program I know of — American Society of Clinical Oncology’s myConnection — is a stuffy, ⊕ ASCO boasts as having more than 50,000 members. The two largest “communities” on MyConnection, “New Member” and “Women in Oncology”, have more than 9,000 members each yet the last post on one was 9 days ago (with zero replies) and 7 days ago (two replies). All of November, the more active WiO group had 9 posts with median 1 reply (range 0–20). formal messaging board that can barely be considered active. Most of ASCO’s online activity is still on X, where the official account has almost 150,000 followers and the hashtag for its annual meeting is heavily promoted. Other large hematology/oncology societies like ASH (hematology) and AACR (general cancer research) don’t even have that. Their “online community” is a member directory and heavy promotion of in-person conferences, which I can only assume are the true money-makers.

So I have to wonder, do they still deserve to call themselves “societies”? It is, after all, 2025 and much of life has moved online. By not providing an avenue for true internal discussion and instead promoting public debate, are they hurting their members' cause more than helping? ⊕ Yes, it was fun to post out in public when there was a slight chance that your favorite celebrity — or the POTUS — would retweet your post, but we have since learned that this is a liability more than a benefit and there are more high-follower accounts on X now that I would rather avoid. I have argued recently that scientists may want to button up their conversations if they are to keep or regain trust. Should these societies not be providing the means to do so, and not only once per year in a stuffy conference room? ASCO’s MyConection is on the right track, but much too formal. Yes, give people the opportunity to create subgroups and even more private chats as you do now. But if you think debating on X with millions of spectators is healthy, why not give all 50,000-plus members a chance to interact by default, and do so in a format that is not an early 2000s web forum?

Concluding the most recent article, Yancey Strickler provided a toolbox for people to create their own communities which he called the Dark Forest OS, of DFOS. While laudable, this effort is to put it bluntly too artsy fartsy for me. Strickler comes from the world of “creators” whose sensibilities are much different from those of doctors and scientists. But then science and medicine already have much of DFOS in place, from a members list to paying dues. The only thing we need now is for the said societies to build their walled gardens — with an app included! — which they would promote instead of X at the annual meetings and other conferences.

Where a SciMeDFOS would come useful is at smaller scale, for collaborative groups and maybe even large individual labs, where members are known but there are no dues, funds, or IT workers ready to build a custom Twitter clone. If I were to make one now I would probably use Hometown, which is a fork of Mastodon that enables local-only posting, though it being a single person’s passion project makes me a bit reluctant. But then what else do we have, Discord, WhatsApp and Signal? Whatever Dave Winer comes up with in collaboration with Wordpress? Maybe Squarspace could make creating private Twitter clones be as easy as creating websites? I will be on the lookout.

• Oliver Burkeman: Interest is everything. The argument for living a life that is interesting to yourself, with which I agree. I have also learned about type 2 burnout in which “you’re not overworked, you’re just working against your own grain.” That too is interesting.
• Casey Handmer: Antimatter Development Program. A ridiculously (to my untrained in physics mind) detailed writeup of what could be the next generation of rocket fuel. To the above point: Handmer’s interest in the topic is contagious.
• Sacha Fast: One (and another) Gear in the Zettelkasten Machine: A Deep Dive into a Key Mechanism. Another person writing about a topic they love, which is slip-boxes. These kinds of posts are dangerous because this interest too is contagious but unlike Handmer’s is also immediately actionable at home. Caveat lector!
• Tanner Greer: The Making of a Techno-Nationalist Elite. Nominally a book review, actually an essay that surpasses the said book in its coverage of the topic.
• Ben Hunt: World War AI and Nick Maggiulli: Is This How the AI Bubble Pops? with two angles converging on the same conclusion, which is that our interesting times are about to become even more interesting.

Happy Thanksgiving, dear reader!

• Tom Forsyth on Mastodon: “Recent discussion about the perils of doors in gamedev reminded me of a bug caused by a door in a game you may have heard of called Half Life 2.” Parallels in biology immediately come to mind.
• David Roberts on Blue Sky: “In an era filled with tech dipshits who never developed emotionally past the age of 13 & use their wealth to become odious monsters … listen to Steve Wozniak.” We are where we are in big part because there weren’t enough Steve Wonziaks in key industries when it mattered. Or rather, because they by definition bowed out and gave the sociopaths free space to roam.
• Ruxandra Teslo on X: “We should do smth abt this.” The “this” is the threat of clinical trial infrastructure being flooded by the biotech equivalent of AI slop. And many misguided people think that this is a good thing!
• Joe Janizek on Substack: The birth of Advanced Radiology. Or: radiology as chess. Radiology and pathology are the few areas of medicine in which AI may be produce immediate benefit.
• Nassim Taleb on Substack: Medical Mistakes with Probability, 2. Why the benefit of statins in people with barely elevated cholesterol and no other risk factors is grossly overestimated. Note that this constitutes most of the market for statins! My cynical take: Now that they are all out of patent I don’t think anyone would complain about cutting back.