• Joe Wilkins: McDonald’s Pulls Down AI-Generated Holiday Ad After Deluge of Mockery. The offensive ad is still available for viewing, and I am horrified to report that it is in fact on par with non-AI holiday marketing shlock. Every profession that feels collectively threatened by LLMs has spent decades undermining itself and is now reaping what it sowed, and yes I include many medical specialties here.
• Sam Kriss for the NYT: Why Does A.I. Write Like … That? A brilliant essay with illustrations that would make me blow a fuse if I were to see them out in the wild. Kriss has a blog to which I am now subscribed and also seems to post on this new social network for writers called… Substack? And Curtis Yarvin plus the rationalist buffoons hate him? Worth following!
• Christopher Butler: The Last Invention. “The real threat of AI as ‘the last invention’ isn’t that it will actually end human innovation and put us all out to pasture in a withering culture of leisure, but that we’ll believe it will. That we’ll internalize the narrative of our own obsolescence and stop trying. That we’ll mistake the tool for the maker and forget that the heart that yearns past the boundary is what drives everything forward.”
• Andrew Sharp: Netflix and the Flattening of Everything. I am not a fan of Netflix. In fact, I dread the moment when they gobble up the last thing, idea or person standing on their path to entertainment singularity. And yet I stay subscribed.
• Taylor Jessen on Mastodon: Candidate for Post of the Year. The post in question is a screenshot from Bluesky which perfectly demonstrates end-stage enshittifaction of what used to be the capital-I Internet, but that is beside the point which is in fact funny and true.

• Ruxandra Teslo and Jack Scannell: To Get More Effective Drugs, We Need More Human Trials. I maintain that this will be nigh-impossible to do in the US until we break the healthcare ouroboros. AI as used now, to increase the number of drug candidates without making a dent in the speed of actually testing them, will only make things worse.
• Benjamin Mazer for The Atlantic: Yes, Some Children May Have Died From COVID Shots. Indeed, and the attempts to say otherwise can only Streisand the issue that should have been just a footnote to the long list of historical vaccine concerns.
• Simon DeDeo: Advice for Early-Career Academics, Part I: Mentorship. No-nonsense advice I wish I had 20-some years ago. I particularly like the distinction between mentors, supporters, fans, friendly elephants and noble adversaries. Left unmentioned are the many people who don’t have your best interest at heart.
• Michael Levy on YouTube: “Hurrian Hymn no. 6” (c.1400BCE) - Ancient Mesopotamian Musical Fragment. The Hurrian songs come not from Mesopotamia but from Ugarit, a city in what is now northern Syria which was one of many victims of the Late Bronze Age collapse. One would hope this would put to rest any questions on whether the humans of that age were like us, but then there are people alive now who don’t think their contemporaries are anything like them.

Let the year-in-review season begin. First up is flying, courtesy of Flighty. Here’s hoping for fewer miles travelled in 2026!

• Gina Kolata for the NYT: Why Some Doctors Say There Are Cancers That Shouldn’t Be Treated. Is the rise in cancer rates due to overdiagnosing tumors that would have been harmless or a true “epidemic” of deadly malignancies? The answer is “Yes”.
• Alex Telford: Going direct: notes on Eli Lilly at a trillion. Why has the valuation (if not true value) of Eli Lilly skyrocketed while the other big GLP-1 company, Novo Nordisk, is in turmoil? The answer is “tech company mimesis”. Girardian.
• Caasey Handmer: Energy Predictions 2025. What is the future of world energy production? The answer is — and this should not be a surprise — “soral”, but good luck to cloudy countries with a NIMBY attitude towards wind power.
• Ben Werdmuller: Why RSS matters? Because you would not be able to read this without it!

📺 It breaks my heart that Season 5 of Only Murders in the Building immediately descended into toilet humor and pointless self-parody. Five episodes in and we are out — life is too short to spend it on drivel.

• Vincent Rajkumar on X: I’ve been on this platform for 16 years. Here are some tips on how to be productive, and gain influence and credibility on X. Great advice for those attending the 2015 ASH Annual Meeting, but I am not so sure about their utility a decade later. Where is the hematology dark forest?
• Edward Zitron: The Era Of The Business Idiot. The more sociopathic of Taleb’s IYIs become executives; hilarity ensues.
• Cory Doctorow: The Reverse Centaur’s Guide to Criticizing AI. An introduction to Doctorow’s new book, “The Reverse Centaur’s Guide to Life After AI. Astute as ever.
• Chris Arnade: [Why are Americans Unhappy]. Arnade dismantles the $140,000 poverty line idiocy with a side jab at the abundance movement by repeating the insight he has each time he visits a seemingly poorer but more communal part of Europe:

So yes, Americans are materially wealthy and unfulfilled, and the primary problem is cultural—we’ve sacrificed community and meaning to emphasize an archetype built on acquiring as much stuff as possible, but then we have made that unnecessarily hard to do. When you give your citizens a cultural script, built on the material, that promises hard work will lead to success, and then your policy design ensures it doesn’t, people will end up both economically frustrated, as well as spiritually empty, sitting in their living room streaming the latest movie wondering what exactly is the point of life. Or, they will feel they have failed at the material, while also having little else to give them meaning.

It’s Caturday Night Fever (or lack thereof).

• Lily Lynch: How the US Stunted Europe. Short and to the point, no notes. Sufficient to make me re-subscribe to Lynch’s newsletter. She links to her review of Sanna Marin’s biography, which is also no-notes wonderful.
• Chris Person for Aftermath: Horses is Tame. I have never heard of the game Horses before or the controversy surrounding it, so I must assume that Valve, Epic and others who banned it for not sure what exactly have never heard of the Streisand effect. Well done, folks.
• Jim Olds: How Will You Know You’ve Succeeded?. I have panned this career research administrator’s first blog post, but this one was in fact enlightening. You have to keep the funders happy, even if they are an amorphous blob called “the American taxpayer”.
• Dr. Christine Corbett Moran: Scaling Career and Family: Systems Thinking, Public School, Home Enrichment. Advice on raising kids from a couple of scientists/engineers turned entrepreneurs. Useful, if a bit on the spectrum, and I even more thankful we had extensive family support when raising our kids, particularly early on.
• Nick Maggiulli: There is No Substitute for Thinking. What are students who use ChatGPT thinking, if they are thinking at all? Will they be writing texts like the ones above or post AI slop in their middle age? Time will tell.